Dexmedetomidine , epidural anesthesia , fentanyl , lower limb surgery , ropivacaine. Group RD was administered 17 ml of 0. Selective outcomes associated with dexmedetomidine use were also described. Dexmedetomidine pretreatment significantly reduced hyperoxia-induced neurodegeneration in different brain regions of the neonatal rat. The patient tolerated the procedure well and was discharged home.

Published by Elsevier Ltd. As most anesthetic agents will affect ECoG, they should be minimized or stopped prior to any recording. Then operation was started herewith till to the end. Dexmedetomidine ; an adjuvant drug for fast track technique in pediatric cardiac surgery. Further studies in the use of dexmedetomidine for AFOI are warranted.

DEX offers better postoperative analgesia via anti-inflammatory and antioxidation pathway.

It provokes dose-dependent and centrally-mediated sympatholysis. Patients with normal renal function and scheduled for elective CABG were randomized to placebo or to infusion of dexmedetomidine to achieve a pseudo steady-state plasma concentration of 0.

intraoperative dexmedetomidine infusion: Topics by

A randomized clinical trial. The effect of continuous lumbar epidural infusion of ropivacaine 0. A double blind prospective study. Bispectral index monitoring revealed that dexmedetomidine -assisted anesthesia can shorten the recovery time of spontaneous breathing, time to eye opening, and time to laryngeal mask removal.

Mild, even severe pain following implant surgery is extremely to be expected [ 6 ]. We evaluated the feasibility of measuring memory and sedation responses in children during dexmedetomidine sedation for non-painful radiological imaging studies.

dexmedetomidine thesis topics

Though, there have been significant advances in general anaesthesia, surgery in elderly and those with comorbid illness still have thesi attendant morbidity and mortality. Patients were monitored for hemodynamics, recovery time and complications.


The anesthetic management of adolescents undergoing bariatric surgery presents a number of challenges, including increased risk of postoperative opioid-related respiratory depression.

Dexmedetomidine seems to provide clinical benefits due to the reduction of mechanical ventilation and ventilator weaning duration. Postoperative analgesia was prolonged significantly in the RD group DEX is a potent sedative agent and also provides analgesia and anxiolytic and sympatholytic effects and has minimal influence on respiratory physiology. Dexmedetomidine as a Cardioprotector dexmfdetomidine Cardiac Surgery Review.

dexmedetomidine thesis topics

The plasma high-mobility group box 1 level decreased significantly from The equipment used is described and the treatment with superficial X-ray beams, orthovoltage X-ray beams and megavoltage electron beams are discussed. Control group received intraoperative ulinastatin intervention and observation group received intraoperative dexmedetomidine combined with ulinastatin intervention.

Rats were subjected to 1 hour middle cerebral artery occlusion and a 2-hour reperfusion. Footnotes Source of Support: Dexmedetomidine infusion was successfully used as a sedative-analgesic to control the withdrawal-related psychomimetic symptoms and to facilitate smooth detoxification and weaning from opioid and other sedatives.

Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine. After a minute instrumentation and equilibration period, the MAC of sevoflurane was determined in triplicate using the tail clamp technique.

Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Time to sedation, number of intubation attempts, Ramsay sedation scale RSS score, bispectral index BIS, and memory recall were recorded.


Oxidative Medicine and Cellular Longevity

Though none of the patients in either of the groups experienced any respiratory difficulty warranting active intervention but patients in group RD exhibited a significantly a lower PaCO 2 post operatively. Time to first analgesic request, postoperative morphine consumption and the incidence of side effects were also recorded.

A few studies reported that various reactive oxygen species ROS scavengers and antioxidants reduce hyperalgesic behaviours in rat models of persistent pain [ 45 ]. Dexmedetomidine infusion in patients undergoing open nephrolithotomy under general anesthesia was associated with intraoperative hemodynamic stability, which decreases intraoperative blood loss and the need for intraoperative blood transfusion.

The drug is being recently used in neuroanesthesia during awake surgery for brain tumors and in functional neurosurgery. Full Text Available Many patients are admitted to the intensive care unit ICU for acute intoxication, serious complication of overdose, or withdrawal symptoms of illicit drugs.

Patients and surgeons alike appreciate the minimally invasive nature of this procedure, as well as its reversibility. The stability of dexmedetomidine admixtures has previously been tested for 48 hours. Fiberoptic intubation is the gold standard technique dexmedetomidone difficult airway management in patients of temporomandibular joint.

dexmedetomidine thesis topics